Antes de morir asesinado, Jacques Sauniere, el ultimo Gran Maestre de una sociedad secreta que se remonta a la fundacion de los Templarios, transmite a su nieta Sophie una misteriosa clave. Sauniere y sus predecesores, entre los que se encontraban hombres como Isaac Newton o Leonardo Da Vinci, han conservado durante siglos un conocimiento que puede cambiar completamente la historia de la humanidad. Ahora Sophie, con la ayuda del experto en symbologia Robert Langdon, comienza la busqueda de ese secreto, en una trepidante carrera que les lleva de una clave a otra, descifrando mensajes ocultos en los mas famosos cuadros del genial pintor y en las paredes de antiguas catedrales.

While in Paris on business, Harvard symbologist Robert Langdon receives an urgent late-night phone call: the elderly curator of the Louvre has been murdered inside the museum. Near the body, police have found a baffling cipher. While working to solve the enigmatic riddle, Langdon is stunned to discover it leads to a trail of clues hidden in the works of Da Vinci--clues visible for all to see--yet ingeniously disguised by the painter. Langdon joins forces with a gifted French cryptologist, Sophie Neveu, and learns the late curator was involved in the Priory of Sion--an actual secret society whose members included Sir Isaac Newton, Botticelli, Victor Hugo, and Da Vinci, among others. In a breathless race through Paris, London, and beyond, Langdon and Neveu match wits with a faceless powerbroker who seems to anticipate their every move. Unless Langdon and Neveu can decipher the labyrinthine puzzle in time, the Priory's ancient secret--and an explosive historical truth--will be lost forever.